The Influence of Childhood Trauma on the Real‐World Effectiveness of Ketamine in Adults With Treatment‐Resistant Depression
Danica E. Johnson, Nelson B Rodrigues, Rodrigo B. Mansur, Roger S McIntyre, Joshua D. Rosenblat
Acta Psychiatrica Scandinavica April 16, 2025 DOI: 10.1111/acps.13812 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Population | People with treatment-resistant depression |
| Intervention | Ketamine |
| Topics | Depression Esketamine Ketamine |
| Key points | The authors aim to determine whether childhood trauma influences the antidepressant effectiveness of ketamine in treatment-resistant depression, noting that childhood trauma is a risk factor for major depressive disorder and is often associated with reduced response to conventional antidepressants. No results are reported in the abstract. |
Abstract
Childhood trauma is a well‐established risk factor for major depressive disorder (MDD) and is often associated with attenuated response to conventional antidepressant therapies. Ketamine has emerged as an effective treatment for treatment‐resistant depression (TRD), but the impact of childhood trauma on its effectiveness remains unclear. Herein, we aimed to determine whether childhood trauma influences the antidepressant effectiveness of ketamine in TRD.