Correlations between cannabis-induced psychopathology and EEG before and after drug ingestion.
M Koukkou, D Lehmann
Pharmakopsychiatrie, Neuro-Psychopharmakologie September 1978 DOI: 10.1055/s-0028-1094581 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 12 |
| Population | 12 healthy volunteers |
| Intervention | Tetrahydro-Cannabinol (THC) |
| Topics | Cannabis |
| Key findings | The authors report that pre-THC EEG frequency-band measures correlated with later THC-induced body image disturbances and euphoria, and that EEG recorded after THC during periods without experiences correlated with the tendency to have drug-induced experiences. Different EEG parameters predicted visual experiences versus body image disturbances. |
Abstract
The study investigates EEG characteristics in relation to psychopathology. Tetrahydro-Cannabinol (THC) was taken orally by 12 volunteers. The EEG was recorded continuously, and THC-induced psychopathology was assessed by pre- and post-experiment questionnaires. Subjects had to signal THC experiences. EEG measurements (distribution means of frequency bands derived from EEG frequency analysis) before and after THC were correlated with THC induced psychopathology. High correlations were found before THC ingestion, and after THC during periods without experiences. Thus, the pre-drug EEG indicates predisposition to THC induced body image disturbances and euphoria, and the drug-influenced EEG in periods without experiences indicates the tendency to drug-induced experiences. The predicting EEG parameters were different for THC induced visual experiences and for body image disturbances.
Comparable studies
Other observational and cohort studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| High-potency cannabis and the risk of psychosis People with first episode of psychosis and healthy controls from the local population | 2009 | Case-control study | n = 454 |
| Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada Rural aboriginal population | 2013 | Observational study | |
| Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) Otherwise healthy young people | 2000 | Observational | |
| Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study Individuals from the general population in Germany aged 14-24 at baseline | 2011 | Observational cohort | n = 1,923 |
| Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases Patients treated for cannabis-induced psychotic symptoms in Denmark between 1994 and... | 2005 | Observational cohort | n = 535 |