Delta 9-tetrahydrocannabinol: elevation of absolute visual thresholds of rabbits.
S E Rose, W O Dwyer, A L Yehle
Pharmacology, Biochemistry, and Behavior June 1979 DOI: 10.1016/0091-3057(79)90056-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rabbits |
| Intervention | Delta 9-tetrahydrocannabinol (THC) |
| Duration | 24-hour follow-up |
| Measures | method of limits, aversive classical conditioning paradigm |
| Topics | Cannabis |
| Key findings | Both doses of Delta 9-tetrahydrocannabinol, similar to the amount a human ingests from a single cigarette, significantly elevated the absolute visual threshold in all rabbits tested, indicating reduced sensitivity to dim light. Thresholds returned to normal baseline within 24 hours. |
Abstract
The effect of Delta 9-tetrahydrocannabinol (THC) on the ability of rabbits to detect a minimal light stimulus (absolute visual threshold) was examined using the method of limits with an aversive classical conditioning paradigm. Both of two dosage levels of THC, similar to an amount ingested by a human from a single cigarette, significantly elevated the absolute visual threshold of all animals. Normal baseline thresholds, however, returned with 24 hours.
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