Reduced binocular depth inversion as an indicator of cannabis-induced censorship impairment.
H M Emrich, M M Weber, A Wendl, J Zihl, L Von Meyer, W Hanisch
Pharmacology, Biochemistry, and Behavior November 1991 DOI: 10.1016/0091-3057(91)90383-d (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Healthy volunteers |
| Intervention | Cannabis |
| Topics | Cannabis |
| Key findings | Cannabis intake produced a strong impairment of binocular depth inversion in healthy volunteers, according to the authors. They interpret this as support for the idea that cannabis-induced psychedelic states involve an inability of the central nervous system to correct implausible perceptual hypotheses. |
Abstract
Measurements of binocular depth inversion using a stereoscopic slide projection with polarized light were performed in healthy volunteers before and after cannabis intake. Since binocular depth inversion represents an illusion occurring in the perception of semantically meaningful objects projected in a 3-D inverted fashion, the hypothesis can be tested that cannabis-induced "psychedelic states" represent a condition in which the human CNS is unable to correct implausible perceptual hypotheses. The data demonstrate a strong cannabis-induced impairment of binocular depth inversion.
Comparable studies
Other observational and cohort studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| High-potency cannabis and the risk of psychosis People with first episode of psychosis and healthy controls from the local population | 2009 | Case-control study | n = 454 |
| Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada Rural aboriginal population | 2013 | Observational study | |
| Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) Otherwise healthy young people | 2000 | Observational | |
| Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study Individuals from the general population in Germany aged 14-24 at baseline | 2011 | Observational cohort | n = 1,923 |
| Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases Patients treated for cannabis-induced psychotic symptoms in Denmark between 1994 and... | 2005 | Observational cohort | n = 535 |
Citations in the library
Cited by 13
- From drugs to deprivation: a Bayesian framework for understanding models of psychosis Psychopharmacology May 27, 2009
- Gone to Pot – A Review of the Association between Cannabis and Psychosis Frontiers in Psychiatry May 22, 2014
- Human Laboratory Studies on Cannabinoids and Psychosis. Biological Psychiatry April 1, 2016
- Resistance to depth inversion illusions: A biosignature of psychosis with potential utility for monitoring positive symptom emergence and remission in schizophrenia Biomarkers in Neuropsychiatry March 26, 2022
- Music and Psychoactive Substances: Cultural Practices, Adolescent Development and Music Therapy in Addiction Treatment IntechOpen eBooks March 18, 2026
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