Serotonergic modulation of rat pup ultrasonic vocal development: studies with 3,4-methylenedioxymethamphetamine.
J. T. Winslow, T. Insel
Journal of Pharmacology and Experimental Therapeutics July 1, 1990 DOI: 10.1016/s0022-3565(25)12578-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Rat pups |
| Intervention | MDMA |
| Dose | 0.5-10.0 mg/kg single dose; 10 mg/kg once or twice daily on postnatal days 1-4 |
| Duration | Monitored on postnatal days 6, 9, 12 and 15 |
| Measures | ultrasonic isolation calls, locomotor behavior, geotaxis, weight gain, serotonin content, [3H]paroxetine binding, catecholamine concentrations |
| Topics | MDMA Serotonin |
| Key findings | Repeated postnatal MDMA (10 mg/kg on days 1-4) produced lasting, dose-dependent reductions in rat pup ultrasonic isolation calls and reduced cortical serotonin content and terminals, without altering locomotor behavior, geotaxis, or weight gain. Prenatal MDMA exposure did not affect calling or serotonin markers. The authors conclude that serotonergic lesions during a sensitive developmental phase can have long-term selective effects on a behavior critical for mother-infant affiliation. |
Abstract
3,4-Methylenedioxymethamphetamine (MDMA) has previously been shown to destroy serotonin terminals in the rat brain. Despite profound and prolonged loss of serotonin innervation, long-term behavioral effects of MDMA have not previously been reported. In this study, we monitored the short- and long-term effects of MDMA administration on the ultrasonic isolation call of the rat pup. At 30 to 60 min after a single dose of MDMA (0.5-10.0 mg/kg), isolation calls decreased as much as 90%, with a rebound increase in calling noted 10 to 25 h following administration of the highest dose. Repeated administration of 10 mg/kg MDMA (once or twice daily on postnatal days 1-4) resulted in a lasting, dose-dependent decrease in ultrasonic vocalization monitored on days 6, 9, 12 and 15. Concurrent measures of locomotor behavior, geotaxis and weight gain were not altered subsequent to repeated MDMA treatment. Both serotonin content and serotonin terminals (assessed by [3H]paroxetine binding) in cortex were reduced by repeated MDMA treatment, whereas concentrations of catecholamines and their metabolites were unaltered. Repeated prenatal MDMA exposure did not affect postnatal rates of calling or the biochemical markers of serotonin in cortex. Pups lesioned with MDMA postnatally showed not only long-term behavioral and biochemical changes but also altered responsiveness to the serotonin 1B agonist 1-[3-(trifluromethyl)phenyl]piperazine. Taken together, these studies indicate that serotonergic lesions in a sensitive phase of development can have long-term selective effects on the rat pup ultrasonic isolation call, a behavior critical for mother-infant affiliation.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 11
- 3,4-Methylenedioxymethamphetamine (Ecstasy)-Induced Learning and Memory Impairments Depend on the Age of Exposure during Early Development Journal of Neuroscience May 1, 2001
- Exposure to 3,4‐methylenedioxymethamphetamine (MDMA) on postnatal days 11–20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning International Journal of Developmental Neuroscience August 1, 2004
- A developmental comparison of the neurobehavioral effects of ecstasy (MDMA) Neurotoxicology and Teratology October 21, 2006
- Neurotoxic effects of MDMA (“ecstasy”) administration to neonatal rats International Journal of Developmental Neuroscience June 5, 2004
- (+/–)3,4-Methylenedioxymethamphetamine (MDMA) Dose-Dependently Impairs Spatial Learning in the Morris Water Maze after Exposure of Rats to Different Five-Day Intervals from Birth to Postnatal Day Twenty Developmental Neuroscience 2009
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