Stimulus properties of 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) analogs.
Richard A Glennon, M Yousif, G Patrick
Pharmacology, Biochemistry, and Behavior March 1988 DOI: 10.1016/0091-3057(88)90001-9 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal drug discrimination study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Amphetamine DOM S(+)MDMA R(-)MDMA (+/-)MDE S(+)MDE R(-)MDE (+/-)N-OH MDA S(+)N-ethylamphetamine (+/-)N-hydroxyamphetamine |
| Dose | 1.0 mg/kg for amphetamine and DOM training doses; other doses not specified |
| Key points | The DOM discriminative stimulus did not generalize to any of the tested methylenedioxy analogs. The amphetamine stimulus generalized to S(+)MDMA, S(+)N-ethylamphetamine, and (+/-)N-hydroxyamphetamine, but not to R(-)MDMA, (+/-)MDE, S(+)MDE, R(-)MDE, or N-OH MDA. The authors suggest these results are consistent with reports that certain MDA derivatives may have psychoactive effects that are not simply amphetamine- or DOM-like. |
Abstract
Using a standard two-lever operant procedure, groups of rats were trained to discriminate intraperitoneal doses of the phenylisopropylamines (+)amphetamine (1.0 mg/kg) or racemic 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM; 1.0 mg/kg) from saline using a VI 15-sec schedule of reinforcement for food reward. Once trained, the animals were administered doses of several methylenedioxy analogs (MDAs) of phenylisopropylamine including the N-monomethyl [S(+)MDMA and R(-)MDMA], N-monoethyl [(+/-)MDE, S(+)MDE, and R(-)MDE], and the N-hydroxyl [(+/-)N-OH MDA] derivatives. The DOM-stimulus did not generalize to any of these agents. The amphetamine-stimulus generalized to S(+)MDMA, S(+)N-ethylamphetamine and (+/-)N-hydroxyamphetamine, but not to R(-)MDMA, (+/-)MDE, S(+)MDE, R(-)MDE, or N-OH MDA. The present results are consistent with other reports in the literature suggesting that the psychoactive effects of certain MDA derivatives may be other than simply amphetamine- or DOM-like.
Citations in the library
Cited by 31
- 3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”): pharmacology and toxicology in animals and humans Addiction May 1, 1994
- Stereoselective pharmacokinetics of 3,4‐methylenedioxymethamphetamine in the rat Chirality 1990
- Initial characterization of PMMA as a discriminative stimulus. Pharmacology, Biochemistry, and Behavior 1997
- The Neuropsychopharmacology and Toxicology of 3,4‐methylenedioxy‐N‐ethyl‐amphetamine (MDEA) CNS Drug Reviews June 1, 2004
- Pharmacological aspects of the combined use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and gamma-hydroxybutyric acid (GHB): a review of the literature Drug and Alcohol Review July 1, 2005
and 26 more in the library
Cites 10
- Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Journal of Pharmacology and Experimental Therapeutics 1987
- Subjective Reports of the Effects of MDMA in a Clinical Setting Journal of Psychoactive Drugs October 1, 1986
- Hallucinogenic Amphetamine Selectively Destroys Brain Serotonin Nerve Terminals Science September 6, 1985
- Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamine: representatives of a novel therapeutic class Journal of Medicinal Chemistry October 1, 1986
- MDA-ASSISTED PSYCHOTHERAPY WITH NEUROTIC OUTPATIENTS The Journal of Nervous and Mental Disease October 1, 1976
and 5 more in the library