Cannabis with high δ9-THC contents affects perception and visual selective attention acutely: an event-related potential study.
K B E Böcker, J Gerritsen, C C Hunault, M Kruidenier, Tj T Mensinga, J L Kenemans
Pharmacology, biochemistry, and behavior July 2010 DOI: 10.1016/j.pbb.2010.04.008 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized, double-blind, placebo-controlled, crossover study Peer reviewed |
|---|---|
| Sample size | 24 |
| Population | Participants who smoked cannabis cigarettes (likely healthy adults, but not specified) |
| Dose | up to 69.4 mg THC (four doses, placebo included) |
| Duration | Four test days; ERP and performance measured 2 hours after exposure |
| Measures | Event-Related Potentials (ERPs), Occipital Selection Negativity, P300 component |
| Topics | Cannabis |
| Key points | THC exposure up to 69.4 mg decreased task accuracy linearly and increased reaction times linearly, while most attention-related ERP components showed no significant dose effects; only perceptual processing components and P300 amplitude decreased, with the former showing a linear dose-response. The authors argue this reflects a non-selective reduction in attentional resources. |
Abstract
Cannabis intake has been reported to affect cognitive functions such as selective attention. This study addressed the effects of exposure to cannabis with up to 69.4mg Delta(9)-tetrahydrocannabinol (THC) on Event-Related Potentials (ERPs) recorded during a visual selective attention task. Twenty-four participants smoked cannabis cigarettes with four doses of THC on four test days in a randomized, double blind, placebo-controlled, crossover study. Two hours after THC exposure the participants performed a visual selective attention task and concomitant ERPs were recorded. Accuracy decreased linearly and reaction times increased linearly with THC dose. However, performance measures and most of the ERP components related specifically to selective attention did not show significant dose effects. Only in relatively light cannabis users the Occipital Selection Negativity decreased linearly with dose. Furthermore, ERP components reflecting perceptual processing, as well as the P300 component, decreased in amplitude after THC exposure. Only the former effect showed a linear dose-response relation. The decrements in performance and ERP amplitudes induced by exposure to cannabis with high THC content resulted from a non-selective decrease in attentional or processing resources. Performance requiring attentional resources, such as vehicle control, may be compromised several hours after smoking cannabis cigarettes containing high doses of THC, as presently available in Europe and Northern America.