Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat.
Laurent Galineau, Catherine Belzung, Ercem Kodas, Sylvie Bodard, Denis Guilloteau, Sylvie Chalon
Brain research. Developmental brain research February 8, 2005 DOI: 10.1016/j.devbrainres.2004.10.012 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Rat progeny prenatally exposed to MDMA or saline |
| Intervention | MDMA |
| Dose | 10 mg/kg s.c. |
| Duration | From gestational day 13 to 20, assessments from embryonic day 14 to postnatal day 70 |
| Topics | MDMA Serotonin |
| Key points | Prenatal MDMA exposure halved whole-brain 5-HT and 5-HIAA at birth, had no effect on transporter density, but strongly reduced pharmacologically induced dopamine and serotonin release in adulthood and decreased sucrose preference by 20%. |
Abstract
We investigated several aspects of the dopaminergic and serotonergic functions throughout brain development in rats prenatally exposed to MDMA ("ecstasy"). Pregnant rats were treated with MDMA (10 mg/kg s.c.) or saline from the 13th to the 20th day of gestation and studies were conducted on the progeny from both groups: (i) quantification of whole brain contents of DA, 5-HT and metabolites from the 14th day of embryonic life (E14) to weaning (21st day of postnatal life, P21); (ii) quantification of DA and 5-HT membrane transporters by autoradiography from E18 to adult age (P70); (iii) measurement of pharmacologically induced release of DA and 5-HT using microdialysis on adult (P70) freely moving rats; (iv) measurement of sucrose preference in adults (P70). Prenatally MDMA-exposed rats showed (i) a two-fold decrease of whole brain levels of 5-HT and 5-HIAA at P0; (ii) no effect on the DAT and SERT density; (iii) a strongly reduced pharmacologically induced release of DA and 5-HT at P70 in the striatum and hippocampus; and (iv) a significant 20% decrease in sucrose preference at P70. This study suggests that a prenatal exposure to MDMA induces transient and long-term neurochemical and behavioural modifications in dopaminergic and serotonergic functions.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 12
- Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice The International Journal of Neuropsychopharmacology July 9, 2008
- A developmental comparison of the neurobehavioral effects of ecstasy (MDMA) Neurotoxicology and Teratology October 21, 2006
- Prenatal Exposure to Alcohol and 3,4-Methylenedioxymethamphetamine (Ecstasy) Alters Adult Hippocampal Neurogenesis and Causes Enduring Memory Deficits Developmental Neuroscience 2014
- MDMA: interactions with other psychoactive drugs. Pharmacology, Biochemistry, and Behavior October 2011
- Intermittent prenatal MDMA exposure alters physiological but not mood related parameters in adult rat offspring. Behavioural Brain Research January 20, 2010
and 7 more in the library
Cites 9
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- 3,4-Methylenedioxymethamphetamine (Ecstasy)-Induced Learning and Memory Impairments Depend on the Age of Exposure during Early Development Journal of Neuroscience May 1, 2001
- Is the Use of Ecstasy and Hallucinogens Increasing? European Addiction Research 1998
and 4 more in the library