Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain.

Behav Brain Res March 21, 2011 DOI: 10.1016/j.bbr.2011.02.024 (opens in new tab)

Study at a glance

AI-extracted from the abstract

Characteristics	Preclinical study Peer reviewed
Population	Rats
Interventions	Ketamine Imipramine
Topics	Esketamine Ketamine
Key points	The combination of ketamine and imipramine induced antidepressant-like behavior and increased CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain, suggesting enhanced neuroplasticity-related signaling.

Abstract

Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain.

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Study at a glance

Abstract

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