Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression.

Study at a glance

Characteristics	Preclinical study Peer reviewed
Population	Animal models of depression
Intervention	Ketamine
Topics	Depression Esketamine Ketamine
Key points	Ketamine produces rapid and sustained antidepressant-like effects in animal models of depression, and the abstract indicates that AMPA receptor involvement is critical for both phases, suggesting that AMPA receptor activation mediates these effects.

Other preclinical and animal studies on ketamine for depression, most cited first.

Study	Year	Design
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression Rats	2020	Preclinical study
A Single Subanesthetic Dose of Ketamine Relieves Depression-like Behaviors Induced by Neuropathic Pain in Rats Rats with spared nerve injury (neuropathic pain model), sham-operated rats, and control...	2011	Animal experimental study
Comparison of (R)-ketamine and lanicemine on depression-like phenotype and abnormal composition of gut microbiota in a social defeat stress model Susceptible mice after chronic social defeat stress	2017	Preclinical animal study
Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression Susceptible mice in the social defeat stress model	2016	Animal experimental study
Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression Wistar-Kyoto (WKY) rats and Wistar control rats	2020	Preclinical study