MDMA reinstates cocaine-seeking behaviour in mice.
José Manuel Trigo, María Juliana Orejarena, Rafaël Maldonado, Patricia Robledo
European Neuropsychopharmacology June 2009 DOI: 10.1016/j.euroneuro.2008.12.010 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | CD1 mice trained to self-administer cocaine |
| Interventions | MDMA d-amphetamine saline |
| Dose | MDMA 10 mg/kg; d-amphetamine 1 and 2 mg/kg |
| Topics | MDMA |
| Key findings | Acute MDMA (10 mg/kg) reinstated cocaine-seeking behavior in mice after extinction, while d-amphetamine (1 and 2 mg/kg) and saline did not, suggesting MDMA's potential to trigger relapse. |
Abstract
MDMA effects are mediated by monoaminergic systems, which seem to play a central role in cocaine craving and relapse. CD1 mice trained to self-administer cocaine (1 mg/kg/infusion) underwent an extinction procedure in which the cues contingent with drug self-administration remained present. Mice achieving extinction were injected with MDMA (10 mg/kg), d-amphetamine (1 and 2 mg/kg) or saline and tested for reinstatement. Acute MDMA, but not d-amphetamine or saline reinstated cocaine-seeking behaviour in mice in which cocaine self-administration and contingent cues were previously extinguished. Acute MDMA can reinstate cocaine-seeking behaviour in mice.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 7
- Dopaminergic mechanisms of reinstatement of MDMA‐seeking behaviour in rats British Journal of Pharmacology December 30, 2010
- Involvement of 5-HT2A receptors in MDMA reinforcement and cue-induced reinstatement of MDMA-seeking behaviour The International Journal of Neuropsychopharmacology October 14, 2010
- Effects of acute social stress on the conditioned place preference induced by MDMA in adolescent and adult mice Behavioural Pharmacology September 1, 2014
- Neurochemical substrates of the rewarding effects of MDMA: implications for the development of pharmacotherapies to MDMA dependence. Behavioural Pharmacology April 2016
- MDMA: interactions with other psychoactive drugs. Pharmacology, Biochemistry, and Behavior October 2011
and 2 more in the library
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