JavaScript is disabled in your browser. You can still read and search, but features like search previews, menus, and forms may not work until it's enabled.

Tolerance to 3,4-methylenedioxymethamphetamine is associated with impaired serotonin release.

Addict Biol May 11, 2010 DOI: 10.1111/j.1369-1600.2010.00217.x (opens in new tab)

Relevant Not relevant

Study at a glance

AI-extracted from the abstract

Characteristics	Review Peer reviewed
Topics	MDMA Serotonin
Key findings	Argues that tolerance to MDMA is associated with impaired serotonin release, indicating that repeated exposure reduces the drug's ability to stimulate serotonin release.

Abstract

Tolerance to 3,4-methylenedioxymethamphetamine is associated with impaired serotonin release.

Tolerance and cross-tolerance to the activating effects of 3,4-methylenedioxymethamphetamine and a 5-hydroxytryptamine1B agonist. J Pharmacol Exp Ther October 1, 1992
3,4-Methylenedioxymethamphetamine, serotonin and memory. J Pharmacol Exp Ther August 1, 1993
Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan. Life Sci 1994
Sustained exposure to 3,4-methylenedioxymethamphetamine induces the augmentation of exocytotic serotonin release in rat organotypic raphe slice cultures. J Pharmacol Sci May 19, 2010
Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat. Neuropharmacology December 1987