Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
Addiction Biology 2011 DOI: 10.1111/j.1369-1600.2009.00196.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Population | Rats in a model of depression |
| Intervention | 3 |
| Topics | Depression MDMA |
| Key points | MDMA showed increased effects in a rat model of depression, suggesting it may have antidepressant potential that warrants further investigation. |
Abstract
Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
Comparable studies
Other preclinical and animal studies on MDMA for depression, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA Rats | 2024 | Preclinical study | |
| R-MDDMA is a Safer Analogue of MDMA with Therapeutic Potential. Rats (implied) | 2026 | Preclinical study | |
| MDMA and memory, addiction, and depression: dose-effect analysis Mice | 2022 | Dose-ranging experimental animal study | |
| Acute behavioral effects of co-administration of mephedrone and MDMA in mice. Swiss mice | 2017 | Animal experimental study |
Citations in the library
Cites 18
- Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin neurons in human beings The Lancet October 1, 1998
- Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin Neurotoxicity and Core Body Temperature in the Rat Journal of Neuroscience July 1, 1998
- Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") Journal of Neuroscience August 1, 1995
- The pharmacology of the acute hyperthermic response that follows administration of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) to rats British Journal of Pharmacology 2002
- The Role of Metabolism in 3,4-(±)-Methylenedioxyamphetamine and 3,4-(±)-Methylenedioxymethamphetamine (Ecstasy) toxicity Therapeutic Drug Monitoring March 19, 2004
and 13 more in the library