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Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.

Addict Biol 2011 DOI: 10.1111/j.1369-1600.2009.00196.x (opens in new tab)

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AI-extracted from the abstract

Characteristics	Preclinical study Peer reviewed
Population	Rats in a model of depression
Intervention	3
Topics	Depression MDMA
Key points	MDMA showed increased effects in a rat model of depression, suggesting it may have antidepressant potential that warrants further investigation.

Abstract

Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.

(±)3,4-methylenedioxymethamphetamine ("ecstasy") treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain. J Comp Neurol August 1, 2012 29 citations
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Sustained exposure to 3,4-methylenedioxymethamphetamine induces the augmentation of exocytotic serotonin release in rat organotypic raphe slice cultures. J Pharmacol Sci May 19, 2010
Electrophysiological and structural alterations in striatum associated with behavioral sensitization to (±)3,4-methylenedioxymethamphetamine (Ecstasy) in rats: role of drug context. Neuroscience September 25, 2010
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