A Perhaps Unexpected Role of Norepinephrine in Actions of MDMA
Clinical Pharmacology & Therapeutics July 20, 2011 DOI: 10.1038/clpt.2011.125 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Commentary Peer reviewed |
|---|---|
| Topics | MDMA |
| Citations | 9 |
| Key points | Argues that reboxetine's action on norepinephrine transporters mediates several effects of MDMA, an unexpected finding that offers new insights into MDMA's pharmacodynamics. |
Abstract
In this issue, Hysek and colleagues present new data describing the impact of treatment with reboxetine on the effects produced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in human volunteers. They demonstrate that several effects of MDMA are mediated by reboxetine's actions on norepinephrine (NE) transporters, an unexpected finding. Building on earlier work, their new data provide new insights into the pharmacodynamics of MDMA and other monoamine-releasing agents.
Citations in the library
Cited by 6
- Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans British Journal of Pharmacology March 8, 2012
- α1-Adrenergic Receptors Contribute to the Acute Effects of 3,4-Methylenedioxymethamphetamine in Humans Journal of Clinical Psychopharmacology July 13, 2013
- MDMA (3,4-Methylenedioxymethamphetamine) Analogues as Tools to Characterize MDMA-Like Effects: An Approach to Understand Entactogen Pharmacology Current Neuropharmacology August 1, 2013
- No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA European Journal of Clinical Pharmacology December 2, 2017
- Constructing the ecstasy of MDMA from its component mental organs: Proposing the primer/probe method. Medical Hypotheses February 1, 2016
and 1 more in the library
Cites 3
- The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA (“Ecstasy”) in Humans Clinical Pharmacology & Therapeutics June 15, 2011
- The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3, 4-methylenedioxymethamphetamine (‘Ecstasy’) in healthy volunteers Journal of Psychopharmacology May 1, 2000
- Acute Psychological Effects of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) are Attenuated by the Serotonin Uptake Inhibitor Citalopram Neuropsychopharmacology May 1, 2000