A Perhaps Unexpected Role of Norepinephrine in Actions of MDMA
Clinical Pharmacology & Therapeutics July 20, 2011 DOI: 10.1038/clpt.2011.125 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Commentary Peer reviewed |
|---|---|
| Topics | MDMA |
| Citations | 9 |
| Key points | Argues that reboxetine's action on norepinephrine transporters mediates several effects of MDMA, an unexpected finding that offers new insights into MDMA's pharmacodynamics. |
Abstract
In this issue, Hysek and colleagues present new data describing the impact of treatment with reboxetine on the effects produced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in human volunteers. They demonstrate that several effects of MDMA are mediated by reboxetine's actions on norepinephrine (NE) transporters, an unexpected finding. Building on earlier work, their new data provide new insights into the pharmacodynamics of MDMA and other monoamine-releasing agents.