Confirmatory efficacy and safety of circular breathwork versus progressive muscle relaxation in trauma-exposed adults with subclinical depressive symptoms (RESET study HU Berlin, Germany).
Isabel Dziobek, Barbara Breitenstein, Martha N. Havenith, Joshua Neil Hindmarsh, Nina Hartter, Santiago Borja
August 26, 2026 DOI: 10.17605/osf.io/9v8w3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preregistration |
|---|---|
| Population | Adults with trauma exposure and subclinical depressive symptomatology |
| Interventions | Circular breathwork Progressive muscle relaxation |
| Measures | WEMWBS |
| Topics | Breathwork |
| Key points | No results are reported because the preregistration specifies analyses before outcome data are examined. The planned primary outcome is mental well-being as measured by the WEMWBS, comparing circular breathwork against progressive muscle relaxation. |
Abstract
This preregistration specifies the confirmatory efficacy and safety analyses for the main paper of the EX_WELL arm of the RESET Berlin trial. The trial compares circular breathwork against progressive muscle relaxation (PMR), an active, structurally matched comparator, in adults with trauma exposure and subclinical depressive symptomatology. The primary outcome is mental well-being (WEMWBS). Data collection is complete; no outcome data have been analysed or examined by arm at the time of registration. Mechanism, neurophysiology, prediction/moderation and socio-emotional analyses are registered separately. This is a component registration of the RESET project; see the master registration (OSF: k3mab).