Comparative Clinical Trajectories Across Cannabis‐Related and Nonsubstance‐Related Psychoses
A. Mustonen, S. Niemelä, Alexander Denissoff, A. Tanskanen, E. Mittendorfer-Rutz, M. Lähteenvuo, J. Tiihonen, H. Taipale
Acta Psychiatrica Scandinavica April 8, 2026 DOI: 10.1111/acps.70097 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | People with first-episode psychosis, including those with cannabis use disorder or cannabis-induced psychosis and those without substance use disorder |
| Topics | Cannabis |
| Key findings | The study suggests that first-episode psychosis with cannabis use disorder or cannabis-induced psychosis has a substantial disease burden, but detailed clinical trajectories remain unclear and require further investigation. |
Abstract
Research indicates that first‐episode psychosis (FEP) with cannabis use disorder (CUD) carries a substantial disease burden, but more granular clinical trajectories of cannabis‐related psychoses remain unclear. This study examines the clinical trajectories of first clinically diagnosed FEP&CUD and cannabis‐induced psychosis (CIP) in comparison with FEP without substance use disorder (SUD).