Rapid clinical and EEG microstate changes 24 h after intranasal esketamine in major depressive disorder with suicidal ideation: a prospective paired study.
J Affect Disord July 23, 2026 DOI: 10.1016/j.jad.2026.122307 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Prospective paired study Peer reviewed |
|---|---|
| Population | Adults with major depressive disorder and suicidal ideation |
| Intervention | Intranasal esketamine |
| Duration | 24 hours |
| Measures | EEG microstates |
| Topics | Depression Esketamine |
| Key points | Intranasal esketamine was associated with rapid clinical improvement and concurrent changes in EEG microstates at 24 hours, suggesting a potential neurophysiological correlate of its rapid antidepressant and anti-suicidal effects. |
Abstract
Rapid clinical and EEG microstate changes 24 h after intranasal esketamine in major depressive disorder with suicidal ideation: a prospective paired study.