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Hepatic Safety of Ketamine and Esketamine for Treatment-Resistant Depression: A Real-World Cohort Study.

J Clin Psychopharmacol July 28, 2026 DOI: 10.1097/jcp.0000000000002228 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Observational cohort Peer reviewed
Population Patients with treatment-resistant depression
Interventions Ketamine Esketamine
Topics Depression Esketamine Ketamine
Key findings The study indicates that ketamine and esketamine are associated with a low risk of hepatic injury in patients with treatment-resistant depression, supporting their hepatic safety.

Abstract

Hepatic Safety of Ketamine and Esketamine for Treatment-Resistant Depression: A Real-World Cohort Study.