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Psychoactive and Neurobiological Effects of Ketamine in Humans: A Scoping Review of Clinical Evidence.

J Clin Med July 29, 2026 DOI: 10.3390/jcm15155922 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Scoping review Peer reviewed
Topics Esketamine Ketamine
Key findings The review concludes that ketamine has rapid antidepressant effects, especially at subanesthetic doses, but is linked to transient psychotomimetic effects and changes in brain function. The authors propose that more standardized clinical research is necessary to clarify its mechanisms and long-term safety.

Abstract

Psychoactive and Neurobiological Effects of Ketamine in Humans: A Scoping Review of Clinical Evidence.