Discordant signals: How outcome measurement shapes interpretation of ketamine response in treatment-resistant depression.
Journal of Affective Disorders August 10, 2026 DOI: 10.1016/j.jad.2026.122368 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Depression Esketamine Ketamine |
| Key points | Argues that the selection of outcome measures significantly affects how ketamine response is interpreted in treatment-resistant depression, with discordant signals across different tools potentially altering conclusions about efficacy. |
Abstract
Discordant signals: How outcome measurement shapes interpretation of ketamine response in treatment-resistant depression.
Comparable studies
Other theoretical and historical papers on ketamine for depression, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| An Integrative Approach to Ketamine Therapy May Enhance Multiple Dimensions of Efficacy: Improving Therapeutic Outcomes With Treatment Resistant Depression. | 2021 | Theoretical or philosophical paper | |
| Arketamine for cognitive impairment in psychiatric disorders | 2023 | Theoretical or philosophical paper | |
| The Montreal model: an integrative biomedical-psychedelic approach to ketamine for severe treatment-resistant depression | 2023 | Theoretical or philosophical paper | |
| Ketamine in Bipolar Disorder: A Review | 2020 | Theoretical or philosophical paper | |
| Rethinking the role of TRKB in the action of antidepressants and psychedelics. | 2024 | Theoretical or philosophical paper |
Citations in the library
Cites 10
- Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression. New England Journal of Medicine May 24, 2023
- International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators Molecular Psychiatry September 7, 2022
- The therapeutic role of ketamine and esketamine in treating psychopathological domains of depression. Neuropharmacology November 1, 2022
- The effects of ketamine on typical and atypical depressive symptoms Acta Psychiatrica Scandinavica July 17, 2020
- IV low dose ketamine infusions for treatment resistant depression: Results from a five-year study at a free public clinic in an academic hospital. Psychiatry Research May 1, 2024
and 5 more in the library