Trial suggests effectiveness of psilocybin for cocaine use disorder
The Brown University Psychopharmacology Update August 3, 2026 DOI: 10.1002/pu.31488 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | Individuals with cocaine use disorder |
| Interventions | Psilocybin Psychotherapy |
| Topics | Psilocybin |
| Key findings | A single dose of psilocybin combined with psychotherapy led to greater reductions in cocaine use compared to active placebo with psychotherapy, with no serious adverse events reported. |
Abstract
Individuals with cocaine use disorder who received a single dose of psilocybin combined with psychotherapy showed greater reductions in cocaine use relative to active placebo with psychotherapy, a randomized trial has found. No serious adverse events were reported during the trial.