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Convergent neuroimmune signaling underlying rapid antidepressant response to ketamine and psychedelics.

Mol Psychiatry July 28, 2026 DOI: 10.1038/s41380-026-03777-z (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Theoretical or philosophical paper Peer reviewed
Topics Esketamine Ketamine
Key points Argues that ketamine and psychedelics share a convergent neuroimmune signaling mechanism that underlies their rapid antidepressant effects, proposing that modulation of neuroimmune pathways is a key therapeutic target.

Abstract

Convergent neuroimmune signaling underlying rapid antidepressant response to ketamine and psychedelics.