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Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative synthesis of dose-effect patterns in rodent models.

J Psychopharmacol August 3, 2026 DOI: 10.1177/02698811261464979 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Systematic review with quantitative synthesis (meta-analysis) Peer reviewed
Population Rodent models (e.g., rats, mice) in fear conditioning and extinction studies
Key findings Moderate doses of psychedelics appear to enhance fear extinction in rodents, whereas low and high doses show reduced or inconsistent effects, suggesting a dose-response sweet spot.

Abstract

Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative synthesis of dose-effect patterns in rodent models.