Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative synthesis of dose-effect patterns in rodent models.
Journal of Psychopharmacology August 3, 2026 DOI: 10.1177/02698811261464979 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review with quantitative synthesis (meta-analysis) Peer reviewed |
|---|---|
| Population | Rodent models (e.g., rats, mice) in fear conditioning and extinction studies |
| Key findings | Moderate doses of psychedelics appear to enhance fear extinction in rodents, whereas low and high doses show reduced or inconsistent effects, suggesting a dose-response sweet spot. |
Abstract
Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative synthesis of dose-effect patterns in rodent models.
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