Development of a Physiologically Based Pharmacokinetic/Pharmacodynamic Model of Psilocybin/Psilocin from Psilocybe cubensis (Magic Mushroom) in Treatment-Resistant Depression.
Eur J Drug Metab Pharmacokinet August 28, 2026 DOI: 10.1007/s13318-026-01033-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or computational modeling paper Peer reviewed |
|---|---|
| Topics | Depression Psilocybin |
| Key points | Argues that a physiologically based pharmacokinetic/pharmacodynamic model can simulate psilocybin and psilocin exposure and receptor occupancy, offering a tool to optimize dosing for treatment-resistant depression and inform clinical trial design. |
Abstract
Development of a Physiologically Based Pharmacokinetic/Pharmacodynamic Model of Psilocybin/Psilocin from Psilocybe cubensis (Magic Mushroom) in Treatment-Resistant Depression.
In the evidence
This study is part of the evidence base for a synthesis in the library. Here is how each one recorded it.
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Argues that a physiologically based pharmacokinetic/pharmacodynamic model can simulate psilocybin and psilocin exposure and receptor occupancy, offering a tool to optimize dosing for treatment-resistant depression.
Synthesized
Comparable studies
Other theoretical and historical papers on psilocybin for depression, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin-assisted therapy of major depressive disorder using Acceptance and Commitment Therapy as a therapeutic frame | 2020 | Theoretical or philosophical paper | |
| The Yale Manual for Psilocybin-Assisted Therapy of Depression (using Acceptance and Commitment Therapy as a Therapeutic Frame) | 2020 | Theoretical or philosophical paper | |
| Psilocybin-Assisted Compassion Focused Therapy for Depression | 2022 | Theoretical or philosophical paper | |
| Psychedelic-assisted psychotherapy for the treatment of major depression: a synthesis of phenomenological explanations. | 2022 | Theoretical or philosophical paper | |
| Unblinding and demand characteristics in the treatment of depression. | 2023 | Theoretical or philosophical paper |