Protective Effects of Gallic Acid on Oxidative and Inflammatory Markers in the Hippocampus and Prefrontal Cortex of a Ketamine-Induced Schizophrenia-like Model.
Brain Sciences June 23, 2026 DOI: 10.3390/brainsci16070660 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical experimental study Peer reviewed |
|---|---|
| Population | Ketamine-induced schizophrenia-like rat model |
| Intervention | Gallic acid |
| Topics | Esketamine Ketamine |
| Key findings | Gallic acid reduced oxidative and inflammatory markers in the hippocampus and prefrontal cortex of a ketamine-induced schizophrenia-like model, indicating a protective effect against neuroinflammation and oxidative stress. |
Abstract
Protective Effects of Gallic Acid on Oxidative and Inflammatory Markers in the Hippocampus and Prefrontal Cortex of a Ketamine-Induced Schizophrenia-like Model.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |
Citations in the library
Cites 5
- Ketamine: a paradigm shift for depression research and treatment Neuron March 1, 2019
- Schizophrenia: A New Approach. II. Result of a Year's Research Journal of Mental Science 1954
- Antipsychotic effect of diosgenin in ketamine-induced murine model of schizophrenia: Involvement of oxidative stress and cholinergic transmission IBRO Neuroscience Reports January 3, 2024
- Therapeutic effects of transcranial direct current stimulation on ketamine-induced schizophrenia-like behaviors and oxidative stress Medicine Science | International Medical Journal 2023
- Ketamine's schizophrenia-like effects are prevented by targeting PTP1B. Neurobiology of Disease May 17, 2021