Subanesthetic dose of ketamine for the antidepressant effects and the associated cognitive impairments of electroconvulsive therapy in elderly patients—A randomized, double‐blind, controlled clinical study
Lei Zou, S. Min, Qibin Chen, Xiao Li, Li Ren
Brain and Behavior December 11, 2020 DOI: 10.1002/brb3.1775 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Clinical trial Randomized Peer reviewed |
|---|---|
| Population | Elderly patients with depression |
| Interventions | Ketamine Electroconvulsive therapy |
| Dose | low-dose |
| Topics | Esketamine Ketamine |
| Key findings | The abstract does not report specific findings for the elderly population; it states the study explored the efficacy and safety of low-dose ketamine as an adjunctive anesthetic for ECT in this group, building on prior evidence in adults. |
Abstract
We previously confirmed that low‐dose ketamine, as an adjunctive anesthetic for electroconvulsive therapy (ECT) in adult patients with depression, accelerates the effects of ECT and reduces the ECT‐induced learning and memory deficits. This study explored the efficacy and safety of low‐dose ketamine in elderly patients with depression.
Comparable studies
Other non-randomized and open-label trials on ketamine, most cited first.
Citations in the library
Cited by 14
- Ketamine in depression and electroconvulsive therapy Current Opinion in Anaesthesiology October 1, 2021
- Perspectives in treatment-resistant depression: esketamine and electroconvulsive therapy. Wiener klinische Wochenschrift March 1, 2025
- The evidence for ketamine treatment in older adults with psychiatric illness: a scoping review Therapeutic Advances in Chronic Disease October 1, 2025
- Effects of Binaural Beat Music and Esketamine for ECT in the Treatment of Major Depressive Disorder: A Randomized Controlled Trial Protocol. Neuropsychiatric Disease and Treatment 2025
- Esketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of mGluR5 in depressive-like rats. Pharmacology, Biochemistry, and Behavior March 1, 2025
and 9 more in the library
Cites 8
- The effect of a single dose of intravenous ketamine on suicidal ideation: a systematic review and individual participant data meta-analysis American Journal of Psychiatry October 3, 2017
- Ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT): a multicentre, double-blind, randomised, parallel-group, superiority trial The Lancet Psychiatry May 1, 2017
- Ketamine in electroconvulsive therapy for depressive disorder: A systematic review and meta-analysis. Journal of Psychiatric Research September 1, 2018
- Rapid infusion of esketamine for unipolar and bipolar depression: a retrospective chart review Neuropsychiatric Disease and Treatment June 1, 2017
- Effects of Low-Dose Ketamine on the Antidepressant Efficacy and Suicidal Ideations in Patients Undergoing Electroconvulsive Therapy. The Journal of ECT January 6, 2020
and 3 more in the library