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Combining TMS and Ketamine for Treatment-Resistant Depression: Clinical Rationale, Current Evidence, and Practical Guidance.

Focus (Am Psychiatr Publ) July 8, 2026 DOI: 10.1176/appi.focus.20260014 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Review Peer reviewed
Topics Depression Esketamine Ketamine
Key findings Argues that combining TMS and ketamine for treatment-resistant depression is clinically rational and shows preliminary promise, but current evidence is limited and more rigorous research is needed to confirm efficacy and guide clinical use.

Abstract

Combining TMS and Ketamine for Treatment-Resistant Depression: Clinical Rationale, Current Evidence, and Practical Guidance.