Opportunities in Novel Psychotropic Drug Design from Natural Compounds
The International Journal of Neuropsychopharmacology July 26, 2019 DOI: 10.1093/ijnp/pyz042 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Commentary Peer reviewed |
|---|---|
| Topics | Anxiety |
| Keywords | Natural product Psychotropic drug Antidepressant Hallucinogen Natural archaeology Pharmacology Antipsychotic Schizophrenia object-oriented programming |
| Citations | 19 |
| Key points | Argues that natural psychotropic substances, particularly those with hallucinogenic and psychedelic properties and different chemical structures, may serve as new paths to novel psychotropic drug development, given that existing drugs derive from atropine and share limited mechanisms. |
Abstract
Multiple initiatives at the national and international level support natural drug discovery. Psychiatrists and patients are not well informed about natural psychotropics in general. Existing antidepressant and antipsychotic drugs were developed from atropine, a natural product. Subsequent drug developments were largely based on extension and modification of earlier molecular scaffolds. This limits their mechanisms of action to similar neuropathways. Natural psychotropic substances, particularly those with hallucinogenic and psychedelic properties and different chemical structures, may serve as new paths to novel psychotropic drug development.
Citations in the library
Cited by 3
- A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Psychopharmacology April 13, 2019
- Indole Alkaloids from Psychoactive Mushrooms: Chemical and Pharmacological Potential as Psychotherapeutic Agents Biomedicines February 5, 2023
- 1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids? Frontiers in Psychiatry 2021
Cites 19
- The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future. Neuropsychopharmacology April 26, 2017
- Potential Therapeutic Effects of Psilocybin. Neurotherapeutics July 1, 2017
- Survey of subjective "God encounter experiences": Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT PLoS One April 23, 2019
- Novel psychopharmacological therapies for psychiatric disorders: psilocybin and MDMA. The Lancet Psychiatry April 5, 2016
- Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution Psychopharmacology August 13, 2018
and 14 more in the library