Clinical Investigation on the Impact of Cannabis Abuse on Thyroid Hormones and Associated Psychiatric Manifestations in the Male Population
Anum Muzaffar, Sami Ullah, Fazal Subhan, Zahid Nazar, Syed Mehdi Hussain, Fazli Khuda, Abuzar Khan, Ameer Khusro, Muhammad Umar Khayam Sahibzada, Sarah Albogami, Ahmed M. El‐Shehawi, Talha Bin Emran, Binish Javed, Javed Ali
Frontiers in Psychiatry December 3, 2021 DOI: 10.3389/fpsyt.2021.730388 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Prospective multicenter study Peer reviewed |
|---|---|
| Sample size | 80 |
| Population | Cannabis-dependent patients with psychotic symptoms and healthy control subjects |
| Measures | Positive and Negative Syndrome Scale (PANSS) |
| Topics | Cannabis |
| Keywords | Psychopathology Schizoaffective disorder Schizophrenia object-oriented programming Psychosis Effects of cannabis Population Bipolar disorder Mania Mood |
| Citations | 12 |
| Key points | Cannabis abuse did not significantly alter thyroid hormones or cardiovascular parameters, likely due to tolerance, but was associated with significantly higher PANSS scores (positive, negative, general psychopathology, and total) in patients versus controls, suggesting a contributing role in psychotic and manic symptoms. |
Abstract
Cannabis abuse is a common public health issue and may lead to considerable adverse effects. Along with other effects, the dependence on cannabis consumption is a serious problem which has significant consequences on biochemical and clinical symptoms. This study intends to evaluate the harmful effects of the use of cannabis on thyroid hormonal levels, cardiovascular indicators, and psychotic symptoms in the included patients. This prospective multicenter study was conducted on cannabis-dependent patients with psychotic symptoms ( n = 40) vs. healthy control subjects ( n = 40). All participants were evaluated for psychiatric, biochemical, and cardiovascular physiological effects. Patients were selected through Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria and urine samples, exclusively for the evaluation of cannabis presence. Serum thyroid stimulating hormone (TSH), T3, and T4 levels were measured using the immunoassay technique. Patients were assessed for severity of depressive, schizophrenic, and manic symptoms using international ranking scales. Various quantifiable factors were also measured for the development of tolerance by cannabis. Among the patients of cannabis abuse, 47.5% were found with schizophrenia, 20% with schizoaffective symptoms, 10% with manic symptoms, and 22.5% with both manic and psychotic symptoms. In the group–group and within-group statistical analysis, the results of thyroid hormones and cardiovascular parameters were non-significant. The psychiatric assessment has shown highly significant ( p < 0.001) difference of positive, negative, general psychopathology, and total scores [through Positive and Negative Syndrome Scale (PANSS) rating scales] in patients vs. the healthy control subjects. The study revealed that cannabis abuse did not significantly alter thyroid hormones and cardiovascular parameters due to the development of tolerance. However, the cannabis abuse might have a significant contributing role in the positive, negative, and manic symptoms in different psychiatric disorders.
Comparable studies
Other observational and cohort studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| High-potency cannabis and the risk of psychosis People with first episode of psychosis and healthy controls from the local population | 2009 | Case-control study | n = 454 |
| Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada Rural aboriginal population | 2013 | Observational study | |
| Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) Otherwise healthy young people | 2000 | Observational | |
| Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study Individuals from the general population in Germany aged 14-24 at baseline | 2011 | Observational cohort | n = 1,923 |
| Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases Patients treated for cannabis-induced psychotic symptoms in Denmark between 1994 and... | 2005 | Observational cohort | n = 535 |
Citations in the library
Cites 8
- Cannabinoids Elicit Antidepressant-Like Behavior and Activate Serotonergic Neurons through the Medial Prefrontal Cortex Journal of Neuroscience October 24, 2007
- Cannabis use and first-episode psychosis: relationship with manic and psychotic symptoms, and with age at presentation Psychological Medicine May 24, 2013
- Dose-related modulation of event-related potentials to novel and target stimuli by intravenous Δ⁹-THC in humans. Neuropsychopharmacology June 2012
- Cannabis and First-Episode Psychosis: Different Long-term Outcomes Depending on Continued or Discontinued Use Schizophrenia Bulletin November 13, 2009
- Cannabis and psychosis/schizophrenia: human studies European Archives of Psychiatry and Clinical Neuroscience July 16, 2009
and 3 more in the library