Antinociceptive effect of N,N-dimethyltryptamine (DMT) involving serotonergic, opioidergic, cannabinoidergic, and nitrergic systems in PGE2-induced hyperalgesia in rats
Flávia C.S. Fonseca, Daniel P.D. Machado, André D. Cavalcante, Andrea C. Perez, Thiago R.L. Romero, Igor D.G. Duarte
Journal of Pain Research and Management February 14, 2026 DOI: 10.46439/painresearch.2.015 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Longitudinal Cross-sectional Peer reviewed |
|---|---|
| Topics | Anxiety 5-MeO-DMT DMT Serotonin |
| Keywords | Anxiolytic Hallucinogen Hyperalgesia Human studies Nociception Central nervous system Depression economics Animal studies Analgesic Perspective graphical Neuroinflammation Neuropharmacology Endogeny |
Abstract
1. Dos Santos RG, Hallak JEC. Ayahuasca: pharmacology, safety, and therapeutic effects. CNS Spectr. 2024 Nov 20;30(1):e2. 2. Bouso JC, González D, Fondevila S, Cutchet M, Fernández X, Ribeiro Barbosa PC, et al. Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of Ayahuasca: a longitudinal study. PLoS One. 2012;7(8):e42421. 3. Sarris J, Perkins D, Cribb L, Schubert V, Opaleye E, Bouso JC, et al. Ayahuasca use and reported effects on depression and anxiety symptoms: An international cross-sectional study of 11,912 consumers. Journal of Affective Disorders Reports. 2021 Apr 1;4:100098. 4. Dos Santos RG, Osório FL, Crippa JA, Hallak JE.
Citations in the library
Cites 21
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and 16 more in the library