Electroanalytical identification of 25I-NBOH and 2C-I via differential pulse voltammetry: a rapid and sensitive screening method to avoid misidentification.

This paper describes a new electrochemical method for detecting 25I-NBOH, a potent serotonin 5-HT2A receptor agonist found in blotter paper seizures. Because 25I-NBOH is thermolabile, routine gas chromatography-mass spectrometry degrades it, causing misidentification. The authors investigated the voltammetric behavior of 25I-NBOH and 2C-I, then developed a fast, sensitive method using a screen-printed carbon electrode. The method is selective and fully differentiates 25I-NBOH, 2C-I, and 25I-NBOMe. The authors conclude the method is analytically valuable.

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Abstract

25I-NBOH is a new potent serotonin 5-HT2A receptor agonist recently identified in blotter paper seizures. This compound is a thermolabile molecule that undergoes degradation under routine gas chromatography-mass spectrometry analysis leading to misidentification. In this paper, the voltammetric behavior of 25I-NBOH and 2C-I was investigated and their electroanalytical characteristics were determined. A novel, fast and sensitive electrochemical method for the detection of 25I-NBOH using a SPCE is described and all method characteristics demonstrated the method to be analytically valuable. This method is selective and achieves full differentiation between 25I-NBOH, 2C-I and 25I-NBOMe.