Introduction to Ketamine: A Dissociative Anesthetic
May 14, 2019 DOI: 10.64239/pi-vl1401 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Historical analysis |
|---|---|
| Topics | Esketamine Ketamine |
| Key points | Ketamine was developed as a less potent form of PCP and termed a "dissociative anesthetic" due to its effects on perception. It was FDA-approved in 1970 and became popular as a field anesthetic because of its hemodynamic safety. |
Abstract
Ketamine was developed as an anesthetic and less potent form of phencyclidine (PCP) by Drs. Edward Domino and Calvin Stevens. The drug was termed a "dissociative anesthetic" in part because subjects became disconnected from their environment and in part because sensory inputs can reach cortical areas but are not always perceived in association areas. It was approved by the US Food and Drug Administration as an anesthetic in 1970 and quickly gained popularity as a field anesthetic due to its hemodynamic safety.
Comparable studies
Other theoretical and historical papers on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs. | 2014 | Historical analysis | |
| A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics | 2020 | Theoretical or philosophical paper | |
| Neuroscience and the Near-Death Experience: Roles for the NMSA-PCP receptor, the sigma receptor and the endopsychosins | 1990 | Theoretical or philosophical paper | |
| A unified model of ketamine's dissociative and psychedelic properties. | 2022 | Theoretical or philosophical paper | |
| An Integrative Approach to Ketamine Therapy May Enhance Multiple Dimensions of Efficacy: Improving Therapeutic Outcomes With Treatment Resistant Depression. | 2021 | Theoretical or philosophical paper |