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MDMA-Assisted Therapy: Challenges, Clinical Trials, and the Future of MDMA in Treating Behavioral Disorders

Steve O’Brien, David Nutt

Cambridge University Press eBooks January 1, 2025 DOI: 10.1017/9781009585330.008 (opens in new tab) via OpenAlex

Summary

AI-generated from the abstract

MDMA-assisted therapy (MDMA-AT) for PTSD and other behavioral disorders has a complex history, moving from research to recreational use and back to medicine. The chapter argues that despite recent setbacks for its clinical application, MDMA-AT holds potential for transforming psychiatry. It covers pivotal trials and the challenges researchers face, while noting an uncertain future amid ongoing debates over ethics, methodology, and political influence.

Study at a glance

Characteristics Review Peer reviewed
Intervention MDMA-assisted therapy
Topics MDMA
Keywords Clinical trial Psychiatry Internal medicine
Citations 5
Key finding Argues that MDMA-assisted therapy holds potential for transforming psychiatry despite recent clinical setbacks.

Abstract

This chapter explores the complex and controversial path of MDMA-assisted therapy (MDMA-AT) for treating post-traumatic stress disorder (PTSD) and other behavioral disorders. It covers MDMA's history from research to recreation to medicine, the pivotal trials, and the challenges faced by researchers. Despite recent setbacks for the clinical application of MDMA, the chapter argues that it holds potential for transforming psychiatry and discusses the uncertain future amidst ongoing debates over ethics, methodology, and political influence.

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