Effects of mindfulness-based interventions on anxiety and functional recovery in head and neck cancer patients undergoing radiotherapy: A prospective study
Boxiang Zhang, Boyang Li, Zhiyuan Liang, Yuanyuan Zhang, Lucy Yue Lau, Yi Chen, Xiangyue Zeng
Psycho-Oncologie September 29, 2025 DOI: 10.18282/po4522 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Prospective controlled study Peer reviewed |
|---|---|
| Sample size | 100 |
| Population | Patients with head and neck malignancies undergoing curative radiotherapy |
| Intervention | Mindfulness-based intervention |
| Duration | 8-week intervention, 3-month follow-up |
| Topics | Anxiety Meditation |
| Keywords | Psychosocial Psychological intervention Prospective cohort study Depression economics Physical therapy Rehabilitation Patient satisfaction Intervention counseling Adverse effect Cancer Emotional distress |
| Key points | Mindfulness-based intervention reduced anxiety and improved functional outcomes compared to standard care at post-treatment and 3-month follow-up. |
Abstract
Patients with head and neck malignancies frequently experience substantial psychological distress and functional impairment during radiotherapy, yet structured interventions targeting both domains are lacking. This prospective controlled study evaluated the effectiveness of an 8-week mindfulness-based intervention (MBI) program on anxiety and functional recovery in individuals undergoing curative radiotherapy. A total of 100 eligible patients were enrolled and assigned to either the MBI group or a control group receiving standard care. The MBI group participated in weekly guided sessions and daily home practice. Anxiety and functional status were assessed at baseline, post-treatment, and 3-month follow-up using the Hospital Anxiety and Depression Scale – Anxiety subscale (HADS-A) and the Functional Assessment of Cancer Therapy – Head and Neck (FACT–H&N) questionnaire. Compared to controls, the MBI group demonstrated significantly greater reductions in anxiety and improvements in functional outcomes at both post-treatment and follow-up (P < 0.01). Adherence to the program was high, with 84% of participants completing ≥6 sessions, and satisfaction scores averaged 8.9/10. No adverse events were reported. A moderate negative correlation was observed between anxiety and function at follow-up (r = –0.52, P < 0.01), supporting a dual-benefit effect. These findings suggest that mindfulness-based interventions are feasible, well-accepted, and clinically beneficial in reducing emotional distress and supporting functional rehabilitation during radiotherapy. The results advocate for the integration of structured psychosocial approaches into comprehensive cancer care, particularly in high-risk populations.
Comparable studies
Other observational and cohort studies on anxiety, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders Patients with generalized anxiety disorder or panic disorder with or without agoraphobia | 1992 | Observational cohort | n = 22 |
| Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report Patients with a depressive disorder | 2015 | Observational study | |
| Patterning of Cognitive and Somatic Processes in the Self-Regulation of Anxiety: Effects of Meditation versus Exercise Regular practitioners of physical exercise or meditation | 1978 | Retrospective study | n = 77 |
| Dynamic coupling of whole-brain neuronal and neurotransmitter systems Healthy humans | 2020 | Observational study | |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
Citations in the library
Cites 14
- Brief mindfulness training reduces salivary IL-6 and TNF-α in young women with depressive symptomatology. Journal of Consulting and Clinical Psychology June 9, 2016
- Effectiveness of Mindfulness-Based Stress Reduction on Mental Health and Psychological Quality of Life among University Students: A GRADE-Assessed Systematic Review. Evidence-based Complementary and Alternative Medicine 2024
- Mindfulness improves psychological health and supports health behaviour cognitions: Evidence from a pragmatic RCT of a digital mindfulness-based intervention. British Journal of Health Psychology November 1, 2024
- Effectiveness of Web-Based Mindfulness-Based Interventions for Patients With Cancer: Systematic Review and Meta-Analyses. Journal of Medical Internet Research June 25, 2024
- Effects of Mindfulness-Based Cancer Recovery training on anxiety, depression, post-traumatic stress disorder, and cancer-related fatigue in breast neoplasm patients undergoing chemotherapy. Medicine June 7, 2024
and 9 more in the library