Center M Pilot Trial: Integrating Preventive Mental Health Care in Routine Prenatal Care.
Ellen L Tilden, Taylor Shank, Catherine Polan Orzech, Leah R Holmes, Ravyn Granados, Sayehsadat Moosavisahebozamani, David Starr, Aaron B Caughey, Alice M Graham, Kristen L Mackiewicz Seghete
Journal of Midwifery & Women's Health 2024 DOI: 10.1111/jmwh.13709 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Mixed-methods pilot study Qualitative Peer reviewed |
|---|---|
| Sample size | 99 |
| Population | Pregnant people |
| Intervention | group-based |
| Duration | 4-week intervention, 6-week postpartum follow-up |
| Topics | Meditation |
| Keywords | Emotional regulation Health care systems Maternal morbidity Maternal mortality Mechanisms of action Perinatal depression Postpartum depression Prenatal care Telehealth Translational science |
| Registration | NCT06525922 |
| Key points | Depressive symptoms significantly decreased from preintervention to postintervention, and mindfulness capacity significantly increased from preintervention to six weeks postpartum; higher mindfulness at six weeks postpartum predicted fewer depressive symptoms. |
Abstract
Perinatal depression is a leading cause of preventable US maternal morbidity and mortality. Although Mindfulness-Based Cognitive Therapy for Perinatal Depression (MBCT-PD) is highly effective, it faces significant scalability challenges. Center M, a brief, group-based, mindfulness-based cognitive behavioral therapy (CBT) intervention, is an adaptation of MBCT-PD designed to overcome these challenges. The purpose of this pilot study was to evaluate Center M's preliminary acceptability, feasibility, mechanisms of action, and efficacy. In this mixed-methods pilot study, data were collected from 99 pregnant people at 3 time points: preintervention, postintervention, and 6-weeks postpartum (Clinical Trials no. NCT06525922). Participants engaged in 4 one-hour, weekly group telehealth Center M sessions facilitated by social workers. Participants strengthened mindfulness CBT skills using home practice materials between group sessions. Data included self-report measures evaluating depressive symptoms, mindfulness skills, and emotion regulation. Satisfaction was assessed via focus groups or surveys. Depressive symptoms significantly decreased preintervention to postintervention (Patient Health Questionnaire-8 score: preintervention mean [SD] 5.02 [3.52], postintervention mean [SD] 4.23 [2.84]; P = .03), and mindfulness capacity significantly increased preintervention to 6 weeks postpartum (Five Facets of Mindfulness Questionnaire score: preintervention mean [SD] 125.56 [18.68], 6 weeks postpartum mean [SD] 130.10 [17.15]; P = .004). Linear regression analyses indicate that higher mindfulness at 6 weeks postpartum significantly predicted fewer depression symptoms at 6 weeks postpartum (β, -0.07; 95% CI, -0.123 to -0.021, R2 = 0.22; P = .006). Reduction in the use of maladaptive emotion regulation was significantly associated with decreased depressive symptoms at 6 weeks postpartum (β, 0.21; 95% CI, 0.048 to 0.376, R2 = .21; P = .012). Qualitative themes indicated high Center M acceptability and appeal. Our findings support the feasibility, acceptability, and appeal of Center M. Results suggest Center M may be effective in reducing depression and enhancing mindfulness skills. Future research must confirm these initial findings to more widely address Center M implementation capacity and sustainability.
Comparable studies
Other non-randomized and open-label trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Mindfulness-Based Stress Reduction in Relation to Quality of Life, Mood, Symptoms of Stress, and Immune Parameters in Breast and Prostate Cancer Outpatients Early-stage breast and prostate cancer patients | 2003 | Pre-post intervention study | n = 59 |
| Exploring self‐compassion and empathy in the context of mindfulness‐based stress reduction (MBSR) Community sample | 2010 | Pre-post intervention study | |
| Mindfulness-Based Stress Reduction Lowers Psychological Distress In Medical Students Second-year medical students | 2003 | Prospective nonrandomized cohort-controlled study | n = 302 |
| Intensive meditation training, immune cell telomerase activity, and psychological mediators. Retreat participants and matched controls | 2011 | Controlled trial with wait-list control group | n = 60 |
| The Effectiveness of Mindfulness Training for Children with ADHD and Mindful Parenting for their Parents Children aged 8-12 with ADHD and their parents | 2011 | Within-group waitlist controlled trial | n = 22 |
Citations in the library
Cites 7
- Using Self-Report Assessment Methods to Explore Facets of Mindfulness Assessment January 27, 2006
- Adapting Mindfulness-Based Cognitive Therapy for Perinatal Depression to Improve Access and Appeal of Preventive Care. Journal of Midwifery & Women's Health November 2022
- A Maturing Mindfulness Based Cognitive Therapy Reflects on Two Critical Issues Current Opinion in Psychology January 28, 2019
- The Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) in Real-World Healthcare Services Mindfulness January 12, 2019
- Accessibility and implementation in the UK NHS services of an effective depression relapse prevention programme: learning from mindfulness-based cognitive therapy through a mixed-methods study April 3, 2017
and 2 more in the library