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The effects of mindfulness-based cognitive behavioral group program for patients with intractable disease and high depression.

Yukihiko Ueda

Intractable & rare diseases research August 31, 2025 DOI: 10.5582/irdr.2025.01024 (opens in new tab) via PubMed

Summary

AI-generated from the abstract

A monthly three-session Mindfulness-Based Cognitive Behavioral Group Program (MCBGP), each session lasting 120 minutes and including psychoeducation, self-disclosure, and mindfulness meditation, was tested in 35 adults with intractable diseases. Participants were split into high- and low-depression groups based on a POMS depression cutoff score of 60. In the high-depression group (n = 11), the program significantly reduced health distress, activity limitations, depression, anxiety/tension, anger/irritability, fatigue, and confusion, and improved total quality-of-life scores. No significant improvements were seen in the low-depression group (n = 24). The authors conclude MCBGP improves mental health and quality of life in patients with intractable diseases and comorbid depression.

Study at a glance

Characteristics Pre-post intervention study Peer reviewed
Sample size 35
Population Adults with intractable diseases
Intervention Mindfulness-Based Cognitive Behavioral Group Program (MCBGP)
Duration Three monthly sessions, each 120 minutes
Topics Depression
Keywords Qol Intractable disease Mindfulness meditation
Key finding In patients with intractable diseases and high depression, MCBGP significantly reduced depression, anxiety, anger, fatigue, confusion, health distress, and activity limitations, and improved quality-of-life scores.

Abstract

This study examined the efficacy of a Mindfulness-Based Cognitive Behavioral Group Program (MCBGP) designed to improve the mental health of patients with intractable diseases. Adults (n = 35) with such diseases participated in the study. They were categorized into a high- or low-depression group based on the Profile of Mood States (POMS) depression subscale score of 60 as the cutoff score. MCBGP was conducted monthly over three sessions, each session lasting 120 minutes. Each session consisted of psychoeducation, self-disclosure, and mindfulness meditation. The program outcomes were evaluated using the Stanford University Chronic Disease Self-Management Questionnaire, the POMS, and the World Health Organization Quality of Life instruments. The results showed that in the high-depression group (n = 11), health distress (p = 0.013), activity limitations (p = 0.022), depression (p < 0.001), anxiety/tension (p = 0.002), anger/irritability (p = 0.004), fatigue (p = 0.023), and confusion (p = 0.033) were significantly reduced. The total quality of life scores were significantly improved (p = 0.028) after the program, whereas no significant improvements were observed in the low-depression group (n = 24). It was concluded that the MCBGP was effective in improving mental health outcomes and enhanced the quality of life in patients with intractable diseases and comorbid depression.

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