Severe clinical toxicity caused by 25I-NBOMe confirmed analytically using LC-MS-MS method
Wojciech Waldman, Maria Kała, Wojciech Lechowicz, Dominika Gil, Jacek Sein Anand
Acta Biochimica Polonica October 18, 2018 DOI: 10.18388/abp.2018_2627 (opens in new tab)
Summary
AI-generated from the abstractRhabdomyolysis, though rare, is a serious complication that can arise from various diseases, including poisonings, which are more common causes than trauma. This case report describes a patient who developed exceptionally severe rhabdomyolysis, with creatine kinase levels reaching 516,455 U/L, after ingesting a small dose of a novel psychoactive substance called "Alice in Wonderland." Laboratory analysis confirmed the substance using a validated LC-MS/MS method on a whole blood sample.
Study at a glance
| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A patient who ingested a novel psychoactive substance |
| Key finding | Ingestion of a small dose of "Alice in Wonderland" can cause exceptionally massive rhabdomyolysis with creatine kinase levels up to 516,455 U/L. |
Abstract
Rhabdomyolysis is a relatively rare, but potentially seriouscomplication of various diseases. Muscular injuryand resultant release of electrolytes, myoglobin andother enzymatic proteins e.g. creatine kinase (CK) intocirculation may result in multi-organ failure requiring anextensive treatment. Non-traumatic causes of rhabdomyolysis,like poisonings, appear to be much more frequentthan traumatic causes. We present the case of a patientwho developed exceptionally massive rhabdomyolysis,with CK up to 516 455 U/l, after ingestion of a relativelysmall dose of a novel psychoactive substance knownas “Alice in Wonderland”. Laboratory quantification wasperformed using a validated LC-MS/MS method in awhole blood sample.