Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies.
Giulia Costa, Maria Antonietta De Luca, Gessica Piras, Jacopo Marongiu, Liana Fattore, Nicola Simola
Neural Regeneration Research May 1, 2020 DOI: 10.4103/1673-5374.268895 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Ketamine MDMA |
| Keywords | Nps Cannabinoids Dissociatives Hallucinogens Methamphetamine Methoxetamine Neuroinflammation Neurotoxicity |
| Key findings | Synthetic psychoactive substances elicit peripheral and central toxicity of varying severity in humans and experimental animals. |
Abstract
Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational use of these substances is on the rise among young and adult people. The present review summarizes recent findings on the peripheral and central toxicity elicited by "old" and "new" synthetic psychoactive substances in humans and experimental animals, focusing on amphetamine derivatives, hallucinogen and dissociative drugs and synthetic cannabinoids.