Neuroendocrine Associations Underlying the Persistent Therapeutic Effects of Classic Serotonergic Psychedelics.
Front Pharmacol March 1, 2018 DOI: 10.3389/fphar.2018.00177 (opens in new tab) via PubMed Central
Summary
AI-generated from the abstractClassic serotonergic psychedelics produce therapeutic effects that can persist long after the drug has left the body. This review examines the neuroendocrine mechanisms that may underlie these lasting benefits, focusing on how psychedelics influence hormone systems such as the hypothalamic-pituitary-adrenal (HPA) axis, oxytocin, and prolactin. The authors suggest that psychedelic-induced changes in these neuroendocrine pathways could contribute to sustained improvements in mood, cognition, and behavior. Understanding these associations may help explain the prolonged therapeutic outcomes observed with psychedelic-assisted therapies and guide future research into their mechanisms of action.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Key finding | Classic serotonergic psychedelics may produce persistent therapeutic effects through modulation of neuroendocrine systems including the HPA axis, oxytocin, and prolactin. |
Abstract
Neuroendocrine Associations Underlying the Persistent Therapeutic Effects of Classic Serotonergic Psychedelics.