Electrophysiological Substates of the Brain in Sleep and Wake
Maxwell Ruckstuhl
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Keywords | Electrophysiology Sleep system call Local field potential Electroencephalography Neural activity Depression economics Human brain Premovement neuronal activity Cerebral cortex Neuroscience of sleep Cortex anatomy |
| Key points | REM sleep exhibits substates distinct in eye movement but continuous in neural activity, and ketamine's effect on cortical spiking and LFP differs during a wake substate defined by high pEMG. |
Abstract
The brain shifts frequently between distinct regimes of neural activity with associated electrophysiological and behavioral features. These many brain states have different functions and subserve different goals of the animal. No understanding of the brain can be complete without characterization of its states, of how they are affected by disorders of the brain, and of how treatments are modulated by them. We present findings on the relationship between neural activity and substates of REM sleep and on the variance in ketamine's effect in cortex across substates of wake. Specifically, REM exhibits substates distinct in eye movement but continuous in single-neuron and coordinated activity, while the effect of ketamine on both spiking and LFP differs in character during a substate of wake defined by high pEMG. We discuss potential implications for treatment of depression and analysis of multimodal brain data.