Functional Parcellation of the Default Mode Network: A Large-Scale Meta-Analysis
Shaoming Wang, Lindsey J. Tepfer, Adrienne A. Taren, David V. Smith
Study at a glance
AI-extracted from the abstract| Characteristics | Meta-analysis |
|---|---|
| Topics | Default mode network |
| Key findings | The PCC, TPJ, and MPFC can be subdivided into functionally distinct subcomponents that make unique contributions to specific cognitive processes and health conditions. |
Abstract
Abstract The default mode network (DMN) consists of several regions that selectively interact to support distinct domains of cognition. Of the various sites that partake in DMN function, the posterior cingulate cortex (PCC), temporal parietal junction (TPJ), and medial prefrontal cortex (MPFC) are frequently identified as key contributors. Yet, it remains unclear whether these subcomponents of the DMN make unique contributions to specific cognitive processes and health conditions. To address this issue, we applied a meta-analytic parcellation approach used in prior work. This approach used the Neurosynth database and classification methods to quantify the association between PCC, TPJ, and MPFC activation and specific topics related to cognition and health (e.g., decision making and smoking). Our analyses replicated prior observations that the PCC, TPJ, and MPFC collectively support multiple cognitive functions such as decision making, memory, and awareness. To gain insight into the functional organization of each region, we parceled each region based on its coactivation pattern with the rest of the brain. This analysis indicated that each region could be further subdivided into functionally distinct subcomponents. Taken together, we further delineate DMN function by demonstrating the relative strengths of association among subcomponents across a range of cognitive processes and health conditions. A continued attentiveness to the specialization within the DMN allows future work to consider the nuances in sub-regional contributions necessary for healthy cognition, as well as create the potential for more targeted treatment protocols in various health conditions.
Comparable studies
Other systematic reviews and meta-analyses on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The wandering brain: Meta-analysis of functional neuroimaging studies of mind-wandering and related spontaneous thought processes | 2015 | Meta-analysis | |
| Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling | 2009 | Meta-analysis | |
| The Default Mode Network in Healthy Individuals: A Systematic Review and Meta-Analysis Healthy individuals | 2016 | Systematic review and meta-analysis | |
| Dreaming as mind wandering: evidence from functional neuroimaging and first-person content reports. | 2013 | Systematic review with meta-analytic comparison | |
| Default Mode Network Modulation by Psychedelics: A Systematic Review Participants from included studies | 2022 | Systematic review |
Citations in the library
Cited by 2
- Self-regulation of the posterior cingulate cortex with real-time fMRI neurofeedback augmented mindfulness training in healthy adolescents: A nonrandomized feasibility study Cognitive, Affective, & Behavioral Neuroscience March 15, 2022
- Augmenting mindfulness training through neurofeedback: a pilot study of the pre-post changes on resting-state functional connectivity in typically developing adolescents. Frontiers in Neuroscience 2024
Cites 14
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- The Brain's Default Mode Network Annual Review of Neuroscience May 4, 2015
- Experience sampling during fMRI reveals default network and executive system contributions to mind wandering. Proceedings of the National Academy of Sciences May 26, 2009
- Meditation experience is associated with differences in default mode network activity and connectivity Proceedings of the National Academy of Sciences November 23, 2011
- Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Journal of Cognitive Neuroscience July 6, 2009
and 9 more in the library