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Does mindfulness therapy affect resistance to inflammation? A Comparative Study.

Julia Almikeeva

Open MIND January 1, 2026 DOI: 10.17605/osf.io/gyfut (opens in new tab) via OpenAlex

Summary

AI-generated from the abstract

Mindfulness-based therapy (MBT) can reduce systemic inflammation, as measured by C-reactive protein (CRP) levels, by linking neurological functions like dorsolateral prefrontal cortex activity with immune signals. An experiment with 200 participants tested MBT as an intervention for inflammation triggered by psychological stress and trauma. The findings suggest that mental regulation through mindfulness practice lowers cognitive load and improves physical health, providing evidence that psychological interventions can influence physiological resilience without targeting external pathogens.

Study at a glance

Characteristics Experimental design Peer reviewed
Sample size 200
Population Participants
Intervention Mindfulness-based therapy
Topics Meditation
Keywords Affect linguistics Dorsolateral prefrontal cortex Cognition Mental health Mindfulness-based cognitive therapy
Key finding Mindfulness-based therapy reduces systemic inflammation markers by linking dlPFC activity with immune signals.

Abstract

This research explores the intersection of cognitive psychology and immunology, specifically investigating how mindfulness-based therapy (MBT) influences systemic inflammation markers. While clinical evidence shows that psychological stress and trauma (including childhood experiences) can trigger inflammatory responses without external pathogens, this study examines MBT as a strategic intervention. Utilizing an experimental design with a sample of 200 participants, the study measures C-reactive protein (CRP) levels to analyze the correlation between mindfulness practice and physiological resilience. By linking neurological functions, such as the dorsolateral prefrontal cortex (dlPFC) activity, with immune signals, this work aims to provide evidence-based insights into reducing cognitive load and enhancing physical health through mental regulation.

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