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Meditation Linked to Enhanced MRI Signal Intensity in the Pineal Gland and Reduced Predicted Brain Age.

Emanuele R G Plini, Michael C Melnychuk, Paul M Dockree

Journal of pineal research March 1, 2025 DOI: 10.1111/jpi.70033 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Cross-sectional study Peer reviewed
Sample size 983
Population Long-term meditators (n=14) and controls (n=969)
Intervention Meditation
Topics Meditation
Keywords Brain age Pineal gland
Key findings Long-term meditators exhibit greater pineal gland signal intensity and younger brain age (lower BrainPAD scores) compared to controls, with a positive association between lifetime meditation hours and pineal signal intensity.

Abstract

Growing evidence demonstrates that meditation practice supports cognitive functions, including attention and interoceptive processing, and is associated with structural changes across cortical networks, including prefrontal regions and the insula. However, the extent of subcortical morphometric changes linked to meditation practice is less appreciated. A noteworthy candidate is the pineal gland, a key producer of melatonin, which regulates circadian rhythms that augment sleep-wake patterns and may also provide neuroprotective benefits to offset cognitive decline. Increased melatonin levels, as well as increased fMRI BOLD signal in the pineal gland, have been observed in meditators versus controls. However, it is not known if long-term meditators exhibit structural changes in the pineal gland linked to the lifetime duration of practice. In the current study, we performed voxel-based morphometry (VBM) analysis to investigate: (1) whether long-term meditators (LTMs) (n = 14) exhibited greater pineal gland MRI-derived signal intensity compared to a control group (n = 969), (2) a potential association between the estimated lifetime hours of meditation (ELHOM) and pineal gland signal intensity, and (3) whether LTMs show greater grey matter (GM) maintenance (BrainPAD) that is associated with pineal gland signal intensity. The results revealed greater pineal gland signal intensity and lower BrainPAD scores (younger brain age) in LTMs compared to controls. Exploratory analysis revealed a positive association between ELHOM and greater signal intensity in the pineal gland but not with GM maintenance as measured by BrainPAD score. However, greater pineal signal intensity and lower BrainPAD scores were correlated in LTMs. The potential mechanisms by which meditation influences pineal gland function, hormonal metabolism, and GM maintenance are discussed - in particular, melatonin's roles in sleep, immune response, inflammation modulation, and stem cell and neural regeneration.

Comparable studies

Other cross-sectional and survey studies on meditation, most cited first.

Study Year Design Participants
Construct Validity of the Five Facet Mindfulness Questionnaire in Meditating and Nonmeditating Samples Experienced meditators and nonmeditating comparison groups 2008 Cross-sectional study
Neural Correlates of Dispositional Mindfulness During Affect Labeling Adult participants 2007 Observational cross-sectional n = 27
Assessing mindfulness in children and adolescents: Development and validation of the Child and Adolescent Mindfulness Measure (CAMM). School-aged children and adolescents 2011 Cross-sectional validation study n = 1,413
Mindfulness and self-compassion as predictors of psychological wellbeing in long-term meditators and matched nonmeditators Experienced meditators and demographically matched nonmeditators 2012 Cross-sectional study n = 152
Mechanisms of Action in the Inverse Relationship Between Mindfulness and Psychological Distress Undergraduates 2008 Cross-sectional, correlational

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