A Review of Salvinorin Analogs and their Kappa-Opioid Receptor Activity
Bioorganic & Medicinal Chemistry Letters March 12, 2018 DOI: 10.1016/j.bmcl.2018.03.029 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Salvia divinorum |
| Key findings | Extensive peripheral modifications of salvinorin A have yielded a trove of SAR information, and deeper structural changes are now possible through advances in chemical synthesis. |
Abstract
The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid receptor, an emerging target for next-generation analgesics. Here we review analogs of the salvinorin chemotype and their effects on selectivity, affinity and potency. Extensive peripheral modifications using isolated salvinorin A have delivered a trove of SAR information. More deep-seated changes are now possible by advances in chemical synthesis.