Harnessing neuroplasticity with psychoplastogens: the essential role of psychotherapy in psychedelic treatment optimization.
Jennifer L. Jones
Frontiers in Psychiatry April 8, 2025 DOI: 10.3389/fpsyt.2025.1565852 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Topics | Neuroplasticity Psychedelic-assisted therapy |
| Keywords | Mental health treatment Psychotherapy integration Therapeutic support |
| Citations | 5 |
Abstract
Psychiatric disorders are marked by habitual patterns of thought, emotion, and behavior, and many mental health disorders are resistant to standard treatments (1)(2)(3)(4). For example, symptoms of major depressive disorder include ruminative negative thoughts, pervasive sadness, and lack of goaldirected behavior (5)(6)(7). Similarly, many anxiety and trauma-related disorders are characterized by recurrent, intrusive, fear-based thoughts and patterns of avoidant behaviors (8,9).
Citations in the library
Cited by 4
- Psilocybin Treatment as an Adjunct to Cognitive Behavioral Therapy for Eating Disorders: Therapeutic Rationale & Considerations for Protocol Development. Behavioral Sciences March 6, 2026
- Pharmacological regulation of adult brain neuroplasticity: Synergistic roles of neuropeptide signaling, psychedelics, and synaptic modulators. Molecular and cellular neurosciences March 1, 2026
- Experteninterview zum Thema psychedelisch unterstützte Psychotherapie (PAP) bei Patienten mit behandlungsresistenter Depression (TRD) Psychotherapie-Wissenschaft October 1, 2025
- A Nature-Themed Video Intervention Increases Nature Relatedness in Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder Psychedelic Medicine December 26, 2025
Cites 49
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- Psychedelics Promote Structural and Functional Neural Plasticity Cell Reports June 1, 2018
- Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Neuron July 5, 2021
- Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors Science February 16, 2023
- Psychedelics promote plasticity by directly binding to BDNF receptor TrkB Nature Neuroscience June 1, 2023
and 44 more in the library