Effect of intraoperative and/or postoperative esketamine administration on preventing postpartum depression: A systematic review and meta-analysis.
Jinping Wang, Hui Liu, Xinchuan Wei
Psychiatry Research May 1, 2024 DOI: 10.1016/j.psychres.2024.115890 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review and meta-analysis Randomized Peer reviewed |
|---|---|
| Sample size | 1,277 |
| Population | Women receiving esketamine during or after cesarean delivery |
| Intervention | Esketamine |
| Topics | Ketamine Depression Esketamine |
| Keywords | Postnatal depression Maternal health Mental health treatment Pregnancy complications Postpartum care Anesthesia advances |
| Citations | 9 |
| Key findings | Intraoperative and/or postoperative esketamine significantly reduces the incidence of postpartum depression and early postoperative Edinburgh Postnatal Depression Scores. |
Abstract
This systematic review and meta-analysis aimed to evaluate the impact of intraoperative and/or postoperative esketamine application on the prevention of postpartum depression (PPD). PubMed, Embase, and Web of Science were thoroughly searched for eligible randomized controlled trials (RCTs) regarding the application of esketamine for postnatal depression prevention. Nine RCTs including 1277 participants were involved in the final analysis. It was found that intraoperative and/or postoperative administration of esketamine significantly reduced the PPD incidence and the Edinburgh Postnatal Depression Scores in the early postoperative period. Meanwhile, esketamine lowered the occurrence of postoperative nausea and vomiting with no influence on other psychiatric symptoms.