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Limitations of psychedelic research in animals warrants acknowledgement

Emily Trunnell, Donya Mand

DOI: 10.22541/au.172900389.94347413/v1 (opens in new tab)

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Key points Argues that the animal study by Rakoczy et al. requires additional context regarding test limitations, ethical considerations, and translational capacity due to lack of human data.

Abstract

In a recent publication in British Journal of Pharmacology, Rakoczy, et al. describe the use of animal tissues and behavioral tests to study the potential of psychedelic compounds to benefit human mental health. However, the research warrants additional context regarding the limitations of these behavioral tests, whether the proposed benefits outweigh the harms experienced by the animals used, and whether this study has translational capacity considering its lack of human specimens and data.