Expectancy Effects Cannot Be Neglected in MDMA-Assisted Therapy Research.
L Jacob Flameling, Jacob S Aday, Michiel van Elk
ACS Chemical Neuroscience November 15, 2023 DOI: 10.1021/acschemneuro.3c00692 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | PTSD MDMA |
| Keywords | Humans N-methyl-3,4-methylenedioxyamphetamine Treatment outcome Combined modality therapy Stress disorders, post-traumatic Blinding MDMA-Assisted Psychotherapy Placebo-effects |
| Key points | Argues that expectancy effects are not adequately controlled in MDMA-assisted therapy research, potentially compromising the validity of reported treatment outcomes. |
Abstract
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVViewpointNEXTExpectancy Effects Cannot Be Neglected in MDMA-Assisted Therapy ResearchL. Jacob FlamelingL. Jacob FlamelingInstitute of Psychology, Leiden University, Leiden 2333 AK, The NetherlandsMore by L. Jacob Flamelinghttps://orcid.org/0000-0002-1425-1180, Jacob S. AdayJacob S. AdayDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, United StatesMore by Jacob S. Aday, and Michiel van Elk*Michiel van ElkInstitute of Psychology, Leiden University, Leiden 2333 AK, The Netherlands*Email: [email protected]More by Michiel van Elkhttps://orcid.org/0000-0002-7631-3551Cite this: ACS Chem. Neurosci. 2023, XXXX, XXX, XXX-XXXPublication Date (Web):November 15, 2023Publication History Received26 October 2023Accepted3 November 2023Published online15 November 2023https://doi.org/10.1021/acschemneuro.3c00692© 2023 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0. License Summary*You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below:Creative Commons (CC): This is a Creative Commons license.Attribution (BY): Credit must be given to the creator.View full license*DisclaimerThis summary highlights only some of the key features and terms of the actual license. It is not a license and has no legal value. Carefully review the actual license before using these materials. This publication is Open Access under the license indicated. Learn MoreArticle Views-Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (736 KB) Get e-Alertsclose Get e-Alerts
Comparable studies
Other theoretical and historical papers on MDMA for PTSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The potential use of N-methyl-3,4-methylenedioxyamphetamine (MDMA) assisted psychotherapy in the treatment of eating disorders comorbid with PTSD. | 2021 | Theoretical or philosophical paper | |
| MDMA-assisted psychotherapy for PTSD in adolescents: rationale, potential, risks, and considerations. Adolescents with PTSD | 2024 | Theoretical or philosophical paper | |
| Incorporating MDMA as an Adjunct in Emotionally Focused Couples Therapy With Clients Impacted by Trauma or PTSD | 2019 | Theoretical or philosophical paper | |
| MDMA-assisted therapy: challenges, clinical trials, and the future of MDMA in treating behavioral disorders. | 2025 | Theoretical or philosophical paper | |
| Development of an Australian Clinical Practice Guideline on methylenedioxymethamphetamine (MDMA)-assisted Psychotherapy for Post-traumatic Stress Disorder. People with post-traumatic stress disorder | 2025 | Theoretical or philosophical paper |